phorbol esters

phorbol esters
Polycyclic compounds isolated from croton oil in which two hydroxyl groups on neighbouring carbon atoms are esterified to fatty acids. The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co-carcinogens or tumour promotors, they are diacyl glycerol analogues and activate protein kinase C irreversibly.

Dictionary of molecular biology. 2004.

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  • phorbol — The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of p. found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; p. esters mimic 1,2 diacylglycerol as activators of protein kinase C. * * * phor·bol fȯr… …   Medical dictionary

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